C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/28 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 405/10 (2006.01) C07D 405/14 (2006.01) C07D 409/10 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2643963
The present invention is directed tojcjnnoline compounds of formula (I) that are PDE 1 inhibitors, pharmaceutical compositions containing such compounds and process for preparing such compounds. This invention is also directed to methods of treating diseases treatable by inhibition of PDElO enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
La présente invention concerne des composés de cinnoline de formule (I) qui sont des inhibiteurs de PDE 1, des compositions pharmaceutiques contenant de tels composés et un procédé de fabrication de tels composés. Cette invention concerne également des procédés de traitement de maladies pouvant être traitées par l'inhibition de l'enzyme PDE10, telles que l'obésité, le diabète non insulinodépendant, la schizophrénie, le trouble bipolaire, le trouble obsessionnel-compulsif et analogue.
Arrington Mark P.
Burli Roland
Conticello Richard D.
Gauss Carla Maria
Hitchcock Stephen A.
Amgen Inc.
Arrington Mark P.
Burli Roland
Conticello Richard D.
Gauss Carla Maria
LandOfFree
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