C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/502 (2006.01) A61K 31/5355 (2006.01) A61K 31/536 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2643983
The present invention is directed to certain cinnoline compounds of formula (I) that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and process for preparing such compounds. The invention is also directed to methods of treating diseases treatable by modulation of PDE10 enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
La présente invention concerne certains composés de la formule (I) de la cinnoline inhibiteurs de la PDE10, des compositions pharmaceutiques qui contiennent de tels composés et un procédé pour préparer de tels composés. L'invention concerne aussi des méthodes pour traiter des maladies que l'on peut traiter par modulation de l'enzyme PDE10, telles que l'obésité, un diabète non insulino-dépendant, la schizophrénie, des troubles bipolaires, des troubles obsessionnels compulsifs et similaires.
Arrington Mark P.
Conticello Richard D.
Danca M. Diana
Gauss Carla
Hitchcock Stephen A.
Amgen Inc.
Memory Pharmaceutical Corporation
Osler Hoskin & Harcourt Llp
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