A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2672826
The present invention is in the fields of medicine, public health, immunology, molecular biologyand virology. The invention provides composition comprising a virus-like particle (VLP) linked to atleast one antigen, wherein said antigen is CCR5 PNt domain comprising one looped peptidic structure. The invention also provides a process for producing the composition. The compositions ofthis invention are useful in the production of vaccines, in particular, for the prevention and treatment of HIV infection. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses.
La présente invention appartient aux domaines de la médecine, de la santé publique, de l'immunologie, de la biologie moléculaire et de la virologie. L'invention concerne une composition comprenant une particule de type virus (VLP) liée à au moins un antigène, ledit antigène étant un domaine PNt CCR5 comprenant une structure peptidique à boucle. L'invention concerne également un procédé de fabrication de la composition. Les compositions de cette invention sont utiles dans la fabrication de vaccins, en particulier pour la prévention et le traitement d'une infection par le VIH. De plus, les compositions de l'invention induisent des réponses immunitaires efficaces, en particulier des réponses d'anticorps.
Bachmann Martin
Boshuizen Ronald
Huber Adrian
Jennings Gary
Langedijk Johannes
Cytos Biotechnology Ag
Fetherstonhaugh & Co.
Pepscan Systems Bv
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