Circular dna molecule with conditional origin of...

Details Circular dna molecule with conditional origin of... Circular dna molecule with conditional origin of...

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/50 (2006.01) C07K 14/82 (2006.01) C12N 15/69 (2006.01) C12N 15/70 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2229307

A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence of at least one specific protein foreign to said host cell. A method for preparing same, cells incorporating said DNA molecules and uses thereof in gene therapy are also described.

La présente invention se rapporte à une molécule d'ADN de forme circulaire, utile en thérapie génique, comprenant au moins une séquence nucléique d'intérêt, caractérisée en ce que la région permettant sa réplication comprend une origine de réplication dont la fonctionnalité dans une cellule hôte requiert la présence d'au moins une protéine spécifique et étrangère à ladite cellule hôte. Elle a également pour objet un procédé de préparation correspondant, des cellules incorporant lesdites molécules d'ADN et leurs utilisations en thérapie génique.

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