C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 1/107 (2006.01) C07K 14/535 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C07K 16/30 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2187283
The present invention provides for circularly permuted ligands which possess specificity and binding affinity comparable to or greater than the specificity and binding affinity of the original (unpermuted) ligand. The invention further provides for novel chimeric molecules comprising a circularly permuted ligand joined to one or more molecules of interest.
L'invention concerne des ligands à permutation circulaire dotés d'une spécificité et d'une affinité de liaison comparables ou supérieures à celles du ligand originel (non permuté). Elle conerne aussi des molécules chimériques nouvelles qui comprennent un ligand à permutation circulaire rattaché à une ou plusieurs molécules recherchées.
Kreitman Robert J.
Pastan Ira
Puri Raj K.
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Fetherstonhaugh & Co.
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