Circulating insulin-like growth factor-i and prostate cancer...

Details Circulating insulin-like growth factor-i and prostate cancer... Circulating insulin-like growth factor-i and prostate cancer...

G - Physics

01

N

G01N 33/574 (2006.01) A01N 37/18 (2006.01) A61K 38/00 (2006.01) G01N 33/48 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2319252

Methods of predicting a propensity to develop prostate cancer are presented. The method consists of measuring the IGF status of an individual. Individuals with high IGF status, as compared with normal reference range values, are at increased risk for developing prostate cancer. More particularly, the IGF status may be determined by measuring IGh-I levels and/or IGFBP-3 levels. High IGF and low IGFBP levels are indicative of a high IGF status. A method of determining the prognosis of existing prostate cancers or of monitoring disease progression involves determining the IGF/PSA status of an individual. Individuals with a high IGF/PSA status (both high IGF status and high PSA levels) tend to develop severe prostate cancer and have a poorer overall prognosis.

L'invention concerne un procédé qui permet d'établir si un sujet est susceptible de développer un cancer prostatique. Le procédé consiste à mesurer l'IGF chez un individu. Les individus faisant apparaître un IGF élevé par rapport à l'étendue des valeurs de référence normales présentent une plus grande probabilité de développer un cancer prostatique. Plus particulièrement, on peut déterminer l'IGF en mesurant les taux de l'IGF et/ou les taux de l'IGFBP-3. Des taux de l'IGF élevés et des taux de l'IGFBP faibles renseignent sur la situation de l'IGF. Un procédé permettant de pronostiquer un cancer prostatique existant ou de surveiller l'évolution de la maladie consiste à déterminer l'IGF/PSA chez un individu. Les individus présentant un taux d'IGF/PSA élevé (présence simultanée d'IGF et de PSA dans des proportions élevées) est susceptible de développer un cancer prostatique grave et d'avoir un pronostic global plus sombre.

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