Circumvention of human tumor drug resistance

Details Circumvention of human tumor drug resistance Circumvention of human tumor drug resistance

A - Human Necessities

61

K

A61K 31/52 (2006.01) A61K 9/127 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2045601

2045601 9108743 PCTABS00005 A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function as suicide substrates for DNA repair enzymes. A method of screening nucleoside analogs for utility as antitumor agents and a screening assay to individual recurrent tumors is described.

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