Cis-2,4,5-triaryl-imidazolines

Details Cis-2,4,5-triaryl-imidazolines Cis-2,4,5-triaryl-imidazolines

C - Chemistry, Metallurgy

07

D

C07D 233/22 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) C07D 233/36 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2528119

The present invention provides compounds according to formula (I ) having the designations provided herein, and pharmaceutically acceptable salts and esters thereof These compounds inhibit the interaction of MDM2 protein with a p53- like peptide and have antiproliferative activity.

La présente invention concerne des composés de formule (I) qui ont les désignations mentionnées, ainsi que des sels et des esters de ceux-ci, acceptables d'un point de vue pharmaceutique. Ces composés inhibent l'interaction d'une protéine MDM2 avec un peptide de type p53 et présentent une activité antiprolifération.

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