C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/22 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) C07D 233/24 (2006.01) C07D 233/26 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2599476
There are presented compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein Y1,Y2, X1 ,X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.
L~invention présente des composés, ou des sels pharmaceutiquement acceptables de ces composés, de la formule (I) dans laquelle Y1,Y2, X1 ,X2, X3 et R sont tels que décrits dans la présente application. On croit que ces composés inhibent l~interaction MDM2-p53 et en tant que tels qu~ils auront une activité cellulaire anti-hyperproliférante.
Fotouhi Nader
Haley Gregory Jay
Simonsen Klaus B.
Thanh Vu Binh
Webber Stephen Evan
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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