Cis-2,4,5-triphenyl-imidazolines and their use in the...

Details Cis-2,4,5-triphenyl-imidazolines and their use in the... Cis-2,4,5-triphenyl-imidazolines and their use in the...

C - Chemistry, Metallurgy

07

D

C07D 413/06 (2006.01) A61K 31/4164 (2006.01) A61K 31/422 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/501 (2006.01) C07D 233/22 (2006.01) C07D 233/24 (2006.01) C07D 233/26 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 405/10 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2469187

The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts ad esters thereof, having the designations provides herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity. Formula (I).

L'invention concerne des composés représentés par les formules I et II, ainsi que des sels et esters de ces composés, acceptables sur le plan pharmaceutique, détaillées dans la description, qui inhibent l'interaction de la protéine MDM2 avec un peptide de type p53 et qui possèdent une activité antiproliférative.

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