Cis-9,10-octadecenoamidase

Details Cis-9,10-octadecenoamidase Cis-9,10-octadecenoamidase

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 38/50 (2006.01) C07C 45/45 (2006.01) C07C 49/227 (2006.01) C07C 57/03 (2006.01) C07C 231/12 (2006.01) C07C 233/09 (2006.01) C07C 327/22 (2006.01) C07F 9/54 (2006.01) C12N 9/80 (2006.01) C12N 9/99 (2006.01) C12P 7/64 (2006.01) C12Q 1/34 (2006.01)

Patent

CA 2224426

The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of cis-9,10-octadecenoamidase. Hydrolysis of cis-9,10-octadecenoamide leads to the formation of oleic acid, a compound without soporific activity. Inhibitors of cis-9,10-octadecenoamidase are disclosed to block this activity.

L'activité soporifique de cis-9,10-octadécénoamide et d'autres amides primaires soporifiques d'acides gras est neutralisée par hydrolyse en présence de cis-9,10-octadécénoamidase. L'hydrolyse de cis-9,10-octadécénoamide entraîne la formation d'acide oléique, un composé dépourvu d'activité soporifique. L'invention concerne des inhibiteurs de cis-9,10-octadécénoamidase utiles pour bloquer cette activité.

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