C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) C12N 15/01 (2006.01)
Patent
CA 2721146
The invention relates to identification of a cis-acting diversification activator (DIVAC) that is necessary and sufficient for the activation of diversification in transcription units linked thereto. The invention provides a method for diversification of a target nucleic acid comprising introduc-ing a genetic construct comprising the diversification activator into a recipient cell, wherein the diversification activator is linked to the target nucleic acid.
L'invention porte sur l'identification d'un activateur de diversification agissant en cis (DIVAC) qui est nécessaire et suffisant pour l'activation d'une diversification dans des unités de transcription liées à celui-ci. L'invention porte sur un procédé de diversification d'un acide nucléique cible comprenant l'introduction d'un produit de construction génétique comprenant l'activateur de diversification dans une cellule receveuse, l'activateur de diversification étant lié à l'acide nucléique cible.
Buerstedde Jean-Marie
Caldwell Randolph B.
Schoetz Ulrike
Blake Cassels & Graydon Llp
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesu
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