Cis and trans-3-aryloxy-4- hydroxypyrrolidines and...

Details Cis and trans-3-aryloxy-4- hydroxypyrrolidines and... Cis and trans-3-aryloxy-4- hydroxypyrrolidines and...

C - Chemistry, Metallurgy

07

D

260/323

C07D 207/12 (2006.01) C07D 207/20 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1133495

366 ABSTRACT OF THE INVENTION Cis and trans-3-aryloxy-4-hydroxypyrrolidines and derivatives thereof having the formula: Image (cis and trans isomers) are disclosed wherein R1 is hydrogen, loweralkyl, benzyloxy- carbonyl and N-loweralkylcarbamoyl, R2 is hydrogen, lower alkyl, cycloalkyl, phenylalkyl, benzyloxycarbonyl, carbamoyl, N-loweralkylcarbamoyl, N-diloweralkylcarbamoyl and para- fluorobenzoyl-lower-alkyl; Ar is phenyl, substituted phenyl, 1-naphthyl, 2-naphthyl, 1-indenyl and 2-indenyl and pharma- ceutically acceptable acid addition and quaternary salts thereof. The compounds have antidepressant, antihypertensive and antiarrythmic activity in animals.

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