Cis-imidazolines as mdm2 inhibitors

Details Cis-imidazolines as mdm2 inhibitors Cis-imidazolines as mdm2 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61P 35/00 (2006.01) C07D 233/20 (2006.01) C07D 233/22 (2006.01) C07D 233/26 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2468783

The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity (I) (II).

La présente invention concerne des composés représentés par la formule I et la formule II, ainsi que des sels et des esters acceptables d'un point de vue pharmaceutique de ceux-ci, tels que décrits dans les spécifications, et destinés à inhiber l'interaction de la protéine MDM2 avec un peptide de type p53 et possédant une activité antiproliférative (I) (II).

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