Cis-imidazolines as mdm2 inhibitors

Details Cis-imidazolines as mdm2 inhibitors Cis-imidazolines as mdm2 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 233/24 (2006.01) A61K 31/4164 (2006.01) A61K 31/454 (2006.01) A61P 35/00 (2006.01) C07D 233/22 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2528096

The present invention provides compound according to formula (I) and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53- like peptide and have antiproliferative activity.

L'invention concerne un composé représenté par la formule (I) et des sels et des esters pharmaceutiquement acceptables de ce composé, présentant les désignations décrites, et qui inhibent l'interaction de la protéine MDM2 avec un peptide analogue à p53 et présentent une activité antiproliférative.

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