Cis-platinum(ii) amine ascorbate complexes

Details Cis-platinum(ii) amine ascorbate complexes Cis-platinum(ii) amine ascorbate complexes

C - Chemistry, Metallurgy

07

F

260/366.7

C07F 15/00 (2006.01)

Patent

CA 1154785

Abstract Ascorbate complexes of platinum(II) coordinated to ammonia or monodentate or bidentate amine ligands in a cis configuration represented by the general formula: cis-[Pt(II)A2(X)m(OH)n] wherein A is ammonia or a monodentate alkyl amine ligand; A2 is a bidentate amine ligand; X is the ascorbate moiety; m is from 1 to 2 and n is from 1 to 0 and the sum of m + n is not greater than 2. The compounds are characterized by pronounced anti-tumor activity, high solubility in water, and low animal toxicity.

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