Cis pyrrolidinyl derivatives and their uses

Details Cis pyrrolidinyl derivatives and their uses Cis pyrrolidinyl derivatives and their uses

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/401 (2006.01) A61P 25/00 (2006.01) C07D 207/48 (2006.01)

Patent

CA 2568773

The present invention provides new cis pyrrolidinyl of the formula (I) or (II) in which: R1, R2 or R3 are hydrogen or a carboxy or amino protecting group; R4 to R8 represent hydrogen or an alkyl radical; R9 represents a (R10)n,(-R11)m group wherein R10 is -CO-, -CS-, -O-, -S-, -SO-, -SO2-, -COO-, -CONRa-, - N(Ra)CO-, -CSNRa-, -N(Ra)CS-, -N(Ra)-, Rb, aryl, and R11 is a polar group, and their use for the treatment and/or prophylaxis of a condition associated with altered glutamatergic signalling and/or functions, and/or conditions which can be affected by alteration of glutamate level or signalling.

La présente invention porte sur un nouveau cis pyrrolidinyle de formule (I) ou (II) dans laquelle: R¿1?, R¿2? ou R¿3? représente hydrogène ou un groupe protégeant carboxy ou amino; R¿4? à R¿8? représentent hydrogène ou un radical alkyle; R¿9? représente un groupe (R¿10?)¿n?,(-R¿11?)¿m? dans lequel R¿10? représente -CO-, -CS-, -O-, -S-, -SO-, -SO¿2?-, -COO-, -CONR¿a?-, -N(R¿a?)CO-, -CSNR¿a?-, -N(R¿a?)CS-, -N(R¿a?)-, R¿b?, aryle, et R¿11? représente un groupe polaire, et sur leur utilisation dans le traitement et/ou la prophylaxie d'un état associé à la signalisation glutamatergique modifiée et/ou à des fonctions, et/ou des états pouvant être affectés par la modification du taux ou de la signalisation du glutamate.

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