C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/10 (2006.01) C07H 19/20 (2006.01) C07H 21/00 (2006.01) C07K 1/13 (2006.01) C12M 1/34 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2714630
The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.
La présente invention concerne des procédés et des compositions pour réaliser des réactions illuminées, en particulier des réactions de séquençage, tout en atténuant et/ou prévenant une photodégradation de réactifs qui peut résulter dune illumination prolongée. En particulier, linvention propose des procédés et compositions pour incorporer les agents photoprotecteurs dans des conjugués comprenant des molécules de rapporteur et des polyphosphates de nucléoside.
Emig Robin
Kong Xiangxu
Otto Geoffrey
Shen Gene
Gowling Lafleur Henderson Llp
Pacific Biosciences Of California Inc.
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