C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/75 (2006.01) A61K 38/17 (2006.01) A61K 38/36 (2006.01) C07K 14/47 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2685756
The present invention concerns a chimeric polypeptide, capable of detecting the antibodies generated in rheumatoid arthritis, comprising at least two citrulinated peptide subunits: (i) one derived from the .alpha. or .beta. chain of the fibrin and (ii) a second derived from the filaggrin. In addition, the invention comprises an antigenic composition, a method and a kit for the diagnosis of rheumatoid arthritis, from the detection of the autoantibodies generated during the course of said disease.
La présente invention concerne un polypeptide recombiné, capable de détecter les anticorps générés dans la polyarthrite rhumatoïde, comprenant au moins deux sous-unités peptidiques citrullinées: (i) une provenant de la chaîne alpha ou bêta de la fibrine et (ii) une seconde provenant de la filagrine. L'invention concerne également une composition antigénique, une méthode et une trousse destinées au diagnostic de la polyarthrite rhumatoïde, par détection des auto-anticorps générés par cette maladie.
Gomara Elena Ma Jose
Haro Villar Isabel
Perez Rodriguez Ma Luisa
Sanmarti Sala Raimon
Consejo Superior de Investigaciones Cientificas
Fundacio Clinic Per A. La Recerca Biomedica
Gowling Lafleur Henderson Llp
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