Citrullinated peptides for diagnosing and prognosing...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/47 (2006.01)

Patent

CA 2757444

The present invention provides novel citrullinated peptides, their use in methods for aiding, assisting, improving, or facilitating the diagnosis or prognosis of rheumatic diseases such as rheumatoid arthritis (RA), and methods for identifying novel citrullinated peptides that are immunoreactive with anti-citrullinated protein antibodies (ACPAs). The present invention also provides methods for detecting rheumatoid factor (RF) using novel RF detection reagents as a means to aid, assist, improve, or facilitate the diagnosis or prognosis of rheumatic diseases such as RA. Kits comprising at least one of the novel citrullinated peptides and/or RF detection reagents of the present invention are also provided.

La présente invention porte sur de nouveaux peptides citrullinés, sur leur utilisation dans des procédés d'aide, d'assistance, d'amélioration ou de facilitation du diagnostic ou du pronostic de maladies rhumatismales telles qu'une polyarthrite rhumatoïde (RA), et dans des procédés d'identification de nouveaux peptides citrullinés qui sont immunoréactifs avec des anticorps anti-protéines citrullinées (ACPA). La présente invention porte également sur des procédés de détection du facteur rhumatoïde (RF) à l'aide de nouveaux réactifs de détection de RF en tant que moyens pour aider, assister, améliorer ou faciliter le diagnostic ou le pronostic de maladies rhumatismales telles qu'une RA. L'invention porte également sur des coffrets comprenant au moins un des nouveaux peptides citrullinés et/ou des réactifs de détection de RF.

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