C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2474844
Inhibitors of human Cks1 and human Skp2, including antisense oligonucleotides, methods, and compositions specific for human Cks1 and human Skp2, are provided. Methods of using the compositions for modulating Cks1 expression and Skp2 expression, and for regulating cell growth, particularly tumor cell growth, are also provided.
L'invention concerne des inhibiteurs des protéines humaines Cks1 et Skp2, y compris des oligonucléotides anti-sens, des méthodes et des compositions spécifiques aux protéines humaines Cks1 Skp2. L'invention concerne également des méthodes d'utilisation des compositions dans la modulation de l'expression de Cks1 et de Skp2, et dans la régulation de la croissance cellulaire, en particulier la croissance des cellules tumorales.
Jefferson Anne B.
Reinhard Christoph
Shamoon Blanche-Marie F.
Walter Annette O.
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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