A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
195/96, 260/1.33
A61K 35/74 (2006.01) C07G 11/00 (2006.01) C12P 1/04 (2006.01) C12P 1/06 (2006.01)
Patent
CA 1208148
ABSTRACT OF THE DISCLOSURE A purified isolate of an actinomycete identified as ATCC 39363 is capable of producing a complex of sulfur-containing antibiotic compounds having antitumor activity. Antibiotic compounds CL-1577A and CL-1577B and their closely related congeners are produced by culti- vating isolate ATCC 39363 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1577 complex is produced, and subsequently isolating the complex or one or more of the compounds. The antibiotic compounds CL-1577A, CL-1577B, their congeners, and pharmaceutical compositions comprising these substances together with a suitable carrier are also disclosed.
458000
Bunge Richard H.
French James C.
Hurley Timothy R.
Smitka Tim A.
Tunac Josefino B.
Macrae & Co.
Warner-Lambert Company
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