Cl-1957b antibiotic compound and its production

Details Cl-1957b antibiotic compound and its production Cl-1957b antibiotic compound and its production

C - Chemistry, Metallurgy

07

D

195/87, 260/357.

C07D 309/38 (2006.01) A61K 31/35 (2006.01) C07D 309/22 (2006.01) C07D 309/32 (2006.01) C12P 17/06 (2006.01)

Patent

CA 1232852

ABSTRACT A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti- microbial compound CL-1957B which also exhibits antitumor properties. The antimicrobial compound CL-1957B is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957B compound is produced, and subsequently isolating the compound. The antibiotic compound CL-1957B, its phar- maceutically acceptable salts, and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

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