Clarithromycin formulations having improved bioavailability

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 9/20 (2006.01) A61K 9/14 (2006.01) A61K 31/7048 (2006.01)

Patent

CA 2481271

A pharmaceutical composition includes micronized clarithromycin and exhibits improved dissolution characteristics relative to a pharmaceutical composition that includes unmicronized clarithromycin. The clarithromycin may have a particle size less than approximately 35 microns. One process for preparing an extended release tablet of the clarithromycin includes micronizing the clarithromycin; blending the micronized clarithromycin with one or more rate controlling polymers and pharmaceutically acceptable excipients; granulating the blend; and compressing to form a tablet. To treat a bacterial infection in a mammal in need of treatment, a patient may be administered a pharmaceutical composition that includes micronized clarithromycin.

La présente invention concerne une composition pharmaceutique contenant de la clarithromycine micronisée et présentant des caractéristiques de dissolution améliorées par rapport à une composition pharmaceutique contenant de la clarithromycine non micronisée. La clarithromycine peut posséder une taille de particule inférieure à 35 microns environ. L'invention se rapporte également à un procédé de préparation d'un comprimé à libération prolongée de cette clarithromycine, qui consiste à microniser la clarithromycine; à mélanger la clarithromycine micronisée à un ou plusieurs polymères de régulation du taux de libération ainsi qu'à des excipients pharmaceutiquement acceptables; à transformer le mélange en granulés et à comprimer ces granulés de manière à former des comprimés. Une composition pharmaceutique contenant de la clarithromycine micronisée peut être administrée à un patient atteint d'une infection bactérienne et justiciable d'un traitement adéquat.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Clarithromycin formulations having improved bioavailability does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Clarithromycin formulations having improved bioavailability, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Clarithromycin formulations having improved bioavailability will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-2082069

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.