Class of spiro-linked pyrrolidine-2,5-diones and...

Details Class of spiro-linked pyrrolidine-2,5-diones and... Class of spiro-linked pyrrolidine-2,5-diones and...

C - Chemistry, Metallurgy

07

D

260/243.26, 260/

C07D 471/20 (2006.01) C07D 215/08 (2006.01) C07D 265/36 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01) C07D 471/06 (2006.01) C07D 498/10 (2006.01) C07D 498/20 (2006.01) C07D 513/10 (2006.01) C07D 513/20 (2006.01)

Patent

CA 1254559

ABSTRACT OF THE INVENTION The invention provides a novel spiro-linked pyrrolidine- 2,5-dione of the formula ;- Image [I] wherein X1 and X2 each independently represent a hydrogen, a halogen atom, a lower alkyl or lower alkoxy group; Y is a methylene group, oxygen or sulfur atom; R1, R2, R3 and R4 each independently represent a hydrogen atom, a lower alkyl group or forming a benzene ring together with their adjacent carbon atoms; the base salts thereof with pharmace- utically acceptable cations, and processes for their manufactures. The compounds of formula[I] useful as aldose reductase inhibitors and as therapeutic agents for treatment of chronic diabetic complications are also disclosed.

470547

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