Classification, diagnosis and prognosis of acute myeloid...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2558366

The present invention relates to methods of genetic analysis for the classification, diagnosis and prognosis of acute myeloid leukemia (AML). The invention provides a method for producing a classification scheme for AML comprising the steps of a) providing a plurality of reference samples, said reference samples comprising cell samples from a plurality of reference subjects affected by AML; b) providing reference profiles by establishing a gene expression profile for each of said reference samples individually; c) clustering said individual reference profiles according to similarity, and d) assigning an AML class to each cluster. The invention further relates to a method for classifying the AML of an AML affected subject, to a method for diagnosing AML in a subject, and to a method of determining the prognosis for an AML affected subject.

L'invention porte sur des procédés d'analyse génétique pour la classification, le diagnostic et le pronostic de leucémie myéloïde aiguë (AML). Cette invention concerne un procédé de fabrication d'un schéma de classification d'AML comprenant plusieurs étapes consistant a) à fournir une pluralité d'échantillons de référence, ces échantillons de référence contenant des échantillons de cellule prélevés sur une pluralité de sujets de référence atteints par AML ; b) à fournir des profiles de référence par établissement d'un profile d'expression génétique pour chacun des échantillons de référence individuels, et d) à attribuer une classe AML à chaque groupe. L'invention se rapporte aussi à un procédé de classification de l'AML d'un sujet atteint d'AML, à un procédé de diagnostic d'AML chez un sujet, et à un procédé de détermination du pronostic d'un sujet atteint d'AML.

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