Classification of individuals suffering from cardiovascular...

G - Physics – 01 – N

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G01N 33/53 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2739944

The present invention relates to the method of measuring the YKL-40 level and using this measurement as a prognosis for survival of an individual suffering from heart disease caused by atherosclerosis. The method may be used for classification of individuals in order to optimize treatment or monitoring the individuals during the course of or prior to or after treatment. The individual may suffer from any type of cardiovascular disease or disorder. The method also detects and determines whether diagnostically or prognostically significant levels of YKL-40 molecules are present in a biological sample. Furthermore the level of YKL-40 may be used to predict disease relapse.

La présente invention concerne le procédé de mesure de la concentration de YKL-40 et l'utilisation de cette mesure comme pronostic de la survie d'un individu qui souffre d'une cardiopathie causée par l'athérosclérose. Le procédé peut être utilisé pour la classification des individus afin d'optimiser le traitement ou pour le suivi des individus avant, pendant ou après le traitement. L'individu peut souffrir de tout type de maladie ou de trouble cardiovasculaire. Le procédé détecte et détermine également si des concentrations importantes, selon un aspect diagnostique ou pronostique, de molécules YKL-40 sont présentes dans un échantillon biologique. En outre, la concentration de YKL-40 peut être utilisée pour prédire une rechute.

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