Clathrates of dehydroepiandrosterone and corresponding...

A - Human Necessities – 61 – K

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A61K 31/565 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2355148

The present invention refers to clathrates of dehydroepiandrosterone, possibly in the form of sulphate, in a matrix consisting of a cyclodextrin and optionally comprising a co-solubilization agent, and to the corresponding pharmaceutical compositions suitable for replacement therapy for the treatment of adrenocortical insufficiency, adrenopausal disorders, hypogonadim and xerophtalmia.

La présente invention se rapporte à des clathrates de déhydroépiandrostérone se présentant éventuellement sous la forme de sulfate, dans une matrice de cyclodextrine et comportant éventuellement un agent de co-solubilisation. L'invention se rapporte également à des compositions pharmaceutiques correspondantes adaptées à une thérapie de substitution destinée au traitement de l'insuffisance corticosurrénale.

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