Claudins' underexpression as markers of tumor metastasis

Details Claudins' underexpression as markers of tumor metastasis Claudins' underexpression as markers of tumor metastasis

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2523870

A method for treating cancer in a mammal comprised of administering a therapeutically effective amount of an agent that induces the expression of one or more claudins within a cancerous cell. Preferably the claudin is claudin-3, claudin-4 aor claudin-9. In a preferred method, a nucleic acid that encodes a claudin is administered to the mammal under conditions wherein the nucleic acid is transfected into the cancerous cell and the claudin is produced in the cell. Also disclosed is a method for diagnosing cancer comprising determining the presence of a claudin 3, 4 or 9 in a cell that normally expresses the protein. If the cell does not express the claudin, then it is cancerous.

L'invention porte sur un procédé de traitement du cancer des mammifères consistant à leur administrer une quantité à effet thérapeutique d'un agent qui induit dans une cellule cancéreuse l'expression d'un ou de plusieurs claudins, de préférence des claudins-3, claudins 4 ou claudins-9. Selon le procédé préféré, on administre au mammifère un acide nucléique codant pour un claudin dans des conditions où l'acide nucléique se transfecte dans la cellule cancéreuse et produit le claudin. L'invention porte également sur un procédé de diagnostic du cancer consistant à déterminer la présence de claudins 3, 4 ou 9 dans une cellule qui exprime normalement ces protéines, une cellule n'exprimant pas de claudin étant considérée comme cancéreuse.

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