Clavulanic acid derivatives

Details Clavulanic acid derivatives Clavulanic acid derivatives

C - Chemistry, Metallurgy

07

D

260/299

C07D 498/04 (2006.01) C07D 503/00 (2006.01)

Patent

CA 1081699

ABSTRACT OF THE DISCLOSURE Clavulanic acid ethers of the formula (II) are disclosed: Image (II) wherein R is an inert organic group of up to 18 carbon atoms and A is a group such that CO2A represents a carboxylic acid group or a pharmaceutically acceptable salt or ester thereof. These compounds have anti-bacterial and .beta.-lactamase inhibitory activity. Methods of preparation of the compounds etherification of esters of clavulanic acid.

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