Clavulanic acid derivatives, preparation and use

Details Clavulanic acid derivatives, preparation and use Clavulanic acid derivatives, preparation and use

C - Chemistry, Metallurgy

07

D

260/299, 260/277

C07D 498/04 (2006.01) C07D 307/52 (2006.01) C07D 503/00 (2006.01)

Patent

CA 1137479

ABSTRACT This invention provides the .beta.-lactamase inhibitory compounds of the formula (II) : Image (II) and esters and acid addition salts of esters thereof wherein R1 is an optionally substituted aromatic mono- cyclic or bicyclic heterocyclic group bonded via a carbon atom and R2 is a group CN2R1, a hydrogen atom, a C1-6 alkyl or hydroxyalkyl group, an optionally substituted benzyl group, or a group of the sub-formula (a): Image (a) where Ra is a C1-3 alkyl group, and Rb and Rc are independently hydrogen, C1-3 alkyl or phenyl. The invention also relates to processes for their preparation and pharmaceutical compositions containing them.

326071

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