Clear oil-containing pharmaceutical compositions

Details Clear oil-containing pharmaceutical compositions Clear oil-containing pharmaceutical compositions

A - Human Necessities

61

K

A61K 9/08 (2006.01) A61K 9/00 (2006.01) A61K 9/10 (2006.01) A61K 9/107 (2006.01) A61K 9/12 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 9/66 (2006.01)

Patent

CA 2375083

The present invention relates to pharmaceutical compositions and methods for improved solubilization of triglyc-erides and improved delivery of therapeutic agents. Compositions of the present invention include a triglyceride and a carrier, where the carrier is formed from a combination of at least two surfactants, at least one of which is hydrophilic. Upon dilution with an aqueous solvent, the composition forms a clear, aqueous dispersion of the triglyceride and surfactants. An optional therapeutic agent can be incorporated into the composition, or can be co-administered with the composition. The invention also provides methods of enhancing triglyceride solubility and methods of treatment with therapeutic agents using these compositions.

L'invention concerne des compositions pharmaceutiques et des méthodes permettant d'améliorer la solubilisation de triglycérides et la distribution d'agents thérapeutiques. Les compositions selon l'invention comprennent un triglycéride et un support formé d'une combinaison d'au moins deux tensioactifs, dont l'un au moins est hydrophile. Après avoir été diluée avec un solvant aqueux, la composition forme une dispersion transparente et aqueuse du triglycéride et des tensioactifs. Un agent thérapeutique peut éventuellement être ajouté à la composition ou administré conjointement avec la composition. L'invention concerne également des méthodes permettant d'améliorer la solubilité du triglycéride ainsi que des méthodes de traitement à l'aide d'agents thérapeutiques utilisant ces compositions.

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