Clear ophthalmic solution comprising latanoprost as active...

A - Human Necessities – 61 – K

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Details

A61K 31/5575 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 47/10 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61K 47/34 (2006.01) A61P 27/06 (2006.01)

Patent

CA 2498233

It is intended to provide an improved formulation of latanoprost eye drops. Namely, transparent eye drops containing latanoprost as the active ingredient and benzalkonium chloride as a preservative wherein clouding due to a composition change is prevented by using at least one means selected from the following means 1) to 3). 1) A means of adding a surfactant; 2) a means of using benzalkonium chloride represented by the formula ~C6H5CH2N(CH3)2R~Cl (wherein R represents C12 alkyl)as the benzalkonium chloride; and 3) a means of adding a nonionic isotonic agent as an isotonic agent.

L'invention a pour objet la mise au point d'une formulation améliorée de collyre au latanoprost. Ainsi, l'invention concerne un collyre transparent contenant du latanoprost comme principe actif et du chlorure de benzalconium comme agent de conservation, la turbidité résultant d'un changement de composition pouvant être évitée par au moins l'un des moyens suivants de 1) à 3) : 1) adjonction d'un tensioactif ; 2) utilisation, en tant que chlorure de benzalconium, d'un chlorure de benzalconium représenté par la formule ÝC¿6?H¿5?CH¿2?N(CH¿3?)R¨Cl (R représentant une alkyle en C¿12?) ; et 3) adjonction, en tant qu'agent isotonique, d'un agent isotonique non ionique.

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