Clear, water-miscible, liquid pharmaceutical vehicles and...

A - Human Necessities – 61 – K

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A61K 31/74 (2006.01) A61K 9/00 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01)

Patent

CA 1090252

ABSTRACT OF THE DISCLOSURE Pharmaceutical vehicles for delivery of pharmacologi- cally active chemical materials to mucous membranes, as well as pharmaceutically active compositions containing such vehicles, are provided. The pharmaceutical vehicles are clear, water miscible, physiologically-acceptable, liquid compositions which gel to a thickened, non-flowing and adhering consistency at human body temperature. They are liquid at ambient room temperature and have a gel transition temperature in the range of from about 25°C. to about 40°C. Aqueous solutions of cer- tain polyoxyethylene-polyoxypropylene condensates are suitable vehicles. Also provided are pharmaceutical compositions con- taining added pharmacologically active chemical material, i.e., a drug or medicament. A method of delivering the drug or medi- cament to a mucous membrane is also provided.

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