Clearance of neoplastic cells from mixed cellular...

Details Clearance of neoplastic cells from mixed cellular... Clearance of neoplastic cells from mixed cellular...

A - Human Necessities

61

K

A61K 35/12 (2006.01) A61K 35/76 (2006.01) A61K 38/21 (2006.01) C12N 5/02 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2408251

The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.

L'invention concerne un procédé d'élimination de cellules néoplastiques d'une composition cellulaire mixte, à l'extérieur d'un organisme vivant, au moyen d'un virus qui, sélectivement, infecte et tue les cellules néoplastiques. Ce procédé peut utiliser différents virus pour éliminer des cellules néoplastiques à des fins diverses, notamment pour purger des cellules souches hématopoïétiques avant une transplantation. L'invention concerne également des compositions préparées selon ce procédé, ainsi que des trousses renfermant une combinaison de virus utiles dans ce domaine.

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