Cleavable reagents for specific delivery to disease sites

Details Cleavable reagents for specific delivery to disease sites Cleavable reagents for specific delivery to disease sites

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2470643

A therapeutic reagent to control one or more reactions of the immune system in a host, or to deliver anti-tumour agents, or disease treatment agents to the host. The therapeutic reagent comprises a regulatory moiety and a carrier protein that inactivates or substantially reduces the activity of the regulatory moiety. Also, the therapeutic reagent includes a cleavage site at which cleavage of the therapeutic reagent can occur to free the regulatory moiety from the carrier protein so that the therapeutic reagent can act at a diseased site in the host.

L'invention a trait à un réactif thérapeutique permettant de contrôler une ou plusieurs réactions du système immunitaire dans un hôte, ou de libérer des agents anti-tumeur, ou des agents de traitement de maladies à l'hôte. Lesdits réactifs thérapeutiques comprennent un fragment régulateur et une protéine porteuse qui inactive ou réduit sensiblement l'activité du fragment régulateur. L'agent thérapeutique comprend également un site de clivage où le clivage du réactif thérapeutique peut avoir lieu pour libérer le fragment régulateur de la protéine porteuse de sorte que le réactif thérapeutique puisse agir sur un site pathologique dans l'hôte.

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