Cleavage of antifolate compounds

Details Cleavage of antifolate compounds Cleavage of antifolate compounds

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2619992

A method of combating toxicity caused by an antifolate compound of Formula I, in an individual who has been administered the compound. The method comprises administering an enzyme that has carboxypeptidase G activity to the individual. A method of cleaving a compound comprising a structural fragment of Formula IV, the method comprising contacting the compound comprising the structural fragment of Formula IV with an enzyme that has carboxypeptidase G activity.

Procédé permettant de lutter contre la toxicité engendrée par un composé antifolique de formule I chez un sujet auquel on a administré le composé par administration d'une enzyme à activité de carboxypeptidase G. On décrit aussi un procédé de clivage de composé comprenant un fragment structurel de formule IV, par contact entre le composé en question et une enzyme ayant l'activité susmentionnée.

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