Cleavage of vegf and vegf receptor by wildtype and mutant...

Details Cleavage of vegf and vegf receptor by wildtype and mutant... Cleavage of vegf and vegf receptor by wildtype and mutant...

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01)

Patent

CA 2562729

MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis.

On peut utiliser des protéases de mutéines de MT-SP1 ayant une spécificité altérée pour les molécules cibles qu'elles clivent pour traiter des maladies chez l'homme, telles que le cancer. On peut utiliser le clivage du VEGF ou du VEGFR à certaines séquences de substrat avec des protéases de MT-SP1 de type sauvage et de mutéine pour traiter des pathologies associées à l'angiogenèse.

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