Cleavage site blocking antibody to prohormone proteins and...

Details Cleavage site blocking antibody to prohormone proteins and... Cleavage site blocking antibody to prohormone proteins and...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C12N 5/00 (2006.01) G01N 33/577 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2023250

Abstract of the Disclosure Cleavage site blocking antibody that binds to prohormones, preferable Tumor Necrosis Factor, thereby preventing the formation of prohormone fragment(s) by proteolysis of the prohormone, and uses of the antibody including prophylactic and therapeutic methods to treat disease, and diagnostic assays for determining the amount of the prohormone and prohormone fragments present in a patients body.

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