Clk-peptide and slk-peptide

Details Clk-peptide and slk-peptide Clk-peptide and slk-peptide

A - Human Necessities

61

K

A61K 38/00 (2006.01)

Patent

CA 2515033

The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially greater affinity than to the native triple helical form of collagen type-IV. Methods utilizing such antagonists for therapeutic treatment of tumor growth, tumor metastasis or of restenosis also are described, as are methods to use such antagonists as diagnostic markers of angiogenesis in normal or diseased tissues both in vivo and ex vivo.

La présente invention a trait à des procédés permettant l'inhibition de l'angiogenèse dans un tissu par l'administration d'un antagoniste de liaison spécifique à un collagène de type IV ayant subi une protéolyse ou une dénaturation présentant une affinité sensiblement supérieure à celle de la forme native hélicoïdale triple de collagène de type IV. L'invention a également trait à des procédés d'utilisation de tels antagonistes pour le traitement thérapeutique de croissance tumorale, de métastase tumorale ou de resténose, ainsi que des procédés d'utilisation de tels antagonistes comme marqueurs diagnostiques de l'angiogenèse dans des tissus normaux ou malades tant in vivo que ex vivo.

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