C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/103, 167/129
C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 14/34 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2002869
ABSTRACT The invention relates to cloned genes, or degenerate variants thereof, which encode endothelial-leukocyte adhesion molecule-1 (ELAM- 1), or fragments thereof. Such fragments may be leukocyte or comple- ment-binding. The invention also relates to cloned genes encoding fusion proteins comprising ELAM. The invention also relates to vectors containing the cloned genes of the invention, hosts trans- formed with the vectors, and the protein products expressed therefrom. The invention also relates to pharmaceutical compositions comprising the expressed proteins. The invention also relates to methods for the treatment of inflammation, post reperfusion injury, bacterial infec- tions, vasculitis, leukemia, and methods of inhibiting metastatic spread of tumor cells by administering the pharmaceutical compositions of the invention.
Bevilacqua Michael P.
Gimbrone Michael A.
Seed Brian
Stengelin Siegfried
Brigham And Women's Hospital
Gowling Lafleur Henderson Llp
The General Hospital Corporation
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