Cloned glutamic acid decarboxylase

Details Cloned glutamic acid decarboxylase Cloned glutamic acid decarboxylase

C - Chemistry, Metallurgy

12

N

167/45, 195/1.22

C12N 15/63 (2006.01) A61K 38/51 (2006.01) C12N 1/21 (2006.01) C12N 9/88 (2006.01) C12N 15/60 (2006.01) G01N 33/564 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2040555

cDNA molecules coding for GAD65 polypeptide. The invention provides cDNA molecules comprising a part of the cDNA sequence of GAD65 which encode at least one epitope for autoantibodies to GAD65. The invention also provides cloning vehicles capable of replication and expression comprising cDNA molecules coding for GAD65. The invention further provides for hosts transformed with a vehicle having a cDNA molecule coding for GAD65. In another embodiment, the invention provides for the detection of autoantibodies to GAD65 using the GAD65 polypeptides coded for by the cDNA molecules of the invention.

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