Cloned human alpha 1c adrenergic receptor

Details Cloned human alpha 1c adrenergic receptor Cloned human alpha 1c adrenergic receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2158345

The human adrenergic receptor of the alpha 1C subtype is cloned and used in an in vitro assay to screen for compounds that specifically bind to the human alpha 1C adrenergic receptor, including compounds effective to reduce symptoms of benign prostatic hypertrophy. The invention includes the assay, the cloned human receptor used in the assay, an isolated human alpha 1C adrenergic receptor free of other human proteins, and compounds identified through the use of this novel, cloned receptor, which selectively bind the human alpha 1C adrenergic receptor.

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