Clonidine formulations in a biodegradable polymer carrier

Details Clonidine formulations in a biodegradable polymer carrier Clonidine formulations in a biodegradable polymer carrier

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 31/4162 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2700586

Effective treatments of pain for extended periods of time are pro-vided. Through the administration of an effective amount of clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limit-ed, to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appro-priate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

La présente invention concerne des traitements efficaces contre la douleur durant des périodes prolongées. L'administration d'une quantité efficace de clonidine au niveau ou à proximité d'un site cible permet de soulager la douleur provoquée par diverses sources, parmi lesquelles entre autres, la hernie discale (c'est-à-dire, la sciatique), la spondilothèse, la sténose, le mal au dos d'origine discale et la douleur articulaire, ainsi que la douleur post-opératoire. Lorsque des préparations appropriées sont introduites dans des polymères biodégradables, le soulagement de la douleur peut se prolonger pendant au moins trois jours. Dans certains modes de réalisation, le soulagement peut durer pendant au moins vingt-cinq jours, au moins cinquante jours, au moins cent jours, au moins cent trente-cinq jours ou au moins cent quatre-vingts jours.

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