Cloning and characterization of slc26a6, slc26a1, and...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/705 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2477534

Isolated nucleic acids encoding SLC26A6, SLC26A1, and SLC26A2 anion transporter polypeptides, recombinantly expressed SLC26A6, SLC26A1, and SLC26A2 anion transporter polypeptides, heterologous expression systems for recombinant expression of SLC26A6, SLC26A1, and SLC26A2 anion transporter polypeptides, assay methods employing the same, and methods for modulation of anion transport activity.

L'invention concerne des acides nucléiques codant des polypeptides de transport d'anions SLC26A6, SLC26A1 et SLC26A2, des polypeptides transporteurs d'anions SLC26A6, SLC26A1 et SLC26A2 exprimés par recombinaison, et des polypeptides transporteurs d'anions SLC26A2, des systèmes d'expression hétérologues pour l'expression recombinée des polypeptides de transport d'anions SLC26A6, SLC26A1 et SLC26A2. L'invention concerne en outre des méthodes utilisant ces éléments, et des méthodes servant à moduler l'activité de transport d'anions.

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