C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2385090
The present invention relates to novel polynucleotides that contain peroxisome proliferator response elements (PPREs). The invention also describes vectors and host cells comprising the novel polynucleotides. The invention further describes methods for using the novel polynucleotides, gene therapy applications, diagnostics for syndromes involving insulin resistance, development of proprietary screening strategies for inhibitors of ligands or proteins that bind to, associate with, or interact with the CAP promoter.
La présente invention concerne de nouveaux polynucléotides qui contiennent des éléments de réponse de proliférateur de peroxisome (PPREs). L'invention décrit également des vecteurs et des cellules hôtes renfermant ces nouveaux polynucléotides. L'invention décrit par ailleurs des procédés d'utilisation de ces nouveaux polynucléotides, des applications de thérapie génique, des diagnostics destinés à des syndromes impliquant une résistance à l'insuline, la mise au point de stratégies de criblage de spécialités pour des inhibiteurs de ligands ou de protéines qui se lient, s'associent, ou interagissent avec le promoteur CAP.
Baumann Christian A.
Ribon Vered
Saltiel Alan Robert
Sim & Mcburney
Warner-Lambert Company Llc
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