Cloning and characterization of the complete mage-1 gene

Details Cloning and characterization of the complete mage-1 gene Cloning and characterization of the complete mage-1 gene

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2168582

The complete nucleotide and amino acid sequences of the human MAGE-1 antigen are provided. Peptides from residues of the C- terminal are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against MAGE-1 antigens. The peptides are particularly useful in methods for stimulating the immune response of individuals against MAGE-1 antigens associated with melanomas.

L'invention concerne les séquences complètes des nucléotides et des acides aminés de l'antigène humain MAGE-1. On utilise des peptides provenant de restes de la terminaison C pour définir des épitopes qui stimulent l'activité des lymphocytes T cytotoxiques, à restriction HLA, contre les antigènes de MAGE-1. Ces peptides sont particulièrement utiles dans des procédés permettant de stimuler la réponse immunitaire de sujets contre des antigènes de MAGE-1 associés aux mélanomes.

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