C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 45/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 9/02 (2006.01) C12N 15/12 (2006.01) C12Q 1/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2202087
A method of regulating long-term memory is disclosed. Also disclosed is isolated DNA encoding a cyclic 3', 5'-adenosine monophosphate responsive transcriptional activator, isolated DNA encoding a' antagonist of cyclic 3', 5'-adenosine monophosphate-inducible transcription, isolated DNA encoding an enhancer-specific activator, and isolated DNA encoding a nitric oxide synthase. A method for assessing the effect of a drug on long-term memory formation is also disclosed.
L'invention concerne un procédé de régulation de mémoire à long terme ainsi qu'un ADN isolé codant un activateur transcriptionnel sensible au monophosphate d'adénosine cyclique 3', 5', de l'ADN isolé codant un antagoniste de la transcription inductible par le monophosphate d'adénosine cyclique 3', 5', de l'ADN codant un promoteur spécifique à un activateur, et un ADN isolé codant une synthase d'oxyde nitrique. L'invention porte également sur un procédé permettant d'évaluer l'effet d'un médicament sur la formation de mémoire à long terme.
Regulski Michael
Tully Timothy P.
Yin Jerry Chi-Ping
Borden Ladner Gervais Llp
Cold Spring Harbor Laboratory
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