Cloning and expression of a protein which modulates cellular...

Details Cloning and expression of a protein which modulates cellular... Cloning and expression of a protein which modulates cellular...

C - Chemistry, Metallurgy

12

N

530/13, 195/1.2,

C12N 15/20 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2002862

The gene encoding a protein (L7) which appears to be a part of the human Type I interferon receptor has been cloned and expressed by recombinant DNA techniques. The protein imparts a non-species specific enhanced responsiveness to Type I interferon to transformed cells. The protein is found on the surface of Daudi cells and has structural features characteristic of receptor proteins.

Le gène codant pour une protéine (L7) qui semble faire partie du récepteur de l'interféron humain de type I a été cloné et exprimé au moyen de techniques de l'ADN recombinant. La protéine donne à l'interféron de type I une meilleure sensibilité non spécifique d'une espèce aux cellules transformées. La protéine se trouve à la surface de cellules Daudi et possède les propriétés structurales propres aux protéines réceptrices.

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