Cloning and expression of a variant gene of platelet factor...

C - Chemistry – Metallurgy – 12 – N

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530/13, 195/1.2,

C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 14/52 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/38 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2025020

2025020 9008824 PCTABS00001 The present invention provides for the purification from native sources or the cloning and expression of a variant form of platelet factor 4 and also provides recombinant DNA vectors and methods for the expression and recovery of the platelet factor 4 variant. Also provided are compositions and methods for modulating immune responses in mammals comprising immunomodulating effective amounts of platelet factor 4 variant.

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